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Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), cholestyramine. May potentiate cyclosporine (seizure risk). May antagonize oral anticoagulants (monitor), isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Concomitant neuromuscular blocking agents; increased risk of myopathy. Withdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapy. Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression. Increased GI effects with aspirin, other NSAIDs. Caution with aspirin in hypoprothrombinemia. May suppress reactions to skin tests.
I have never written a review on anything really, but I thought it was important in this case. I have been dealing with arthritis for probably 15 years. I was essentially given two choices: the first is take Allopurinol and hope it prevents me from getting sprouts. However, I would have to take a 20 mg pill every day, and this medication has upset my stomach in the past. Option two is to treat an outbreak when it occurs with the medication. I went this route, and took Colchicine, which is the medication to treat this. The problem is that it never seemed to work, and I recently had a terrible gout attack. I got Prednisone and it really worked miracles. I was probably 70% better after one full day, and now almost 100% after three days. I am more than satisfied with this medication!