Clinical efficacy was evaluated in 2 randomized, double-masked, placebo-controlled trials in which subjects with an anterior chamber cell grade ≥ “2” (a cell count of 11 or higher) after cataract surgery were assigned to DUREZOL or placebo (vehicle) following surgery. One drop of DUREZOL or vehicle was self instilled either 2 times per day or 4 times per day for 14 days, beginning the day after surgery. The presence of complete clearing (a cell count of 0) was assessed 8 and 15 days post-surgery using a slit lamp binocular microscope. In the intent-to-treat analyses of both studies, a significant benefit was seen in the 4 times per day DUREZOL –treated group in ocular inflammation and reduction of pain when compared with placebo. The consolidated clinical trial results are provided below.
While it would be absurd to suggest that family doctors should be aware of the more obscure side effects of all the drugs they prescribe, this situation is rather different. Bendroflumethiazide is one of the commoner drugs prescribed for raised blood pressure and it is well known to cause diabetes in almost 10 per cent of those taking it. So for her family doctor to fail to make the connection is definitely a bit odd. She did the sensible thing and binned her pills. Gratifyingly, her “diabetes” has since cured itself, and for good measure, her blood pressure has also remained satisfactory.