Prelone steroid

Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia.

Some causes of nausea and vomiting may be life threatening, for example, heart attack, abdominal obstruction, and cancers.

Treatment of nausea and vomiting depends upon the cause.

As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. [28]

The following medicines may interact with prednisolone:

  • Medicines to treat high blood pressure
  • Water tablets (diuretics)
  • Digoxin (heart tablet)
  • Medicines for asthma (bambuterol, salbutamol, salmeterol, theophylline)
  • Erythromycin (an antibiotic)
  • Ketoconazole (for fungal infections)
  • Ritonavir (for viral infections)
  • Human growth hormone (somatropin)
  • Medicines for epilepsy (carbamazepine, phenobarbital, other barbiturates, phenytoin, primidone, phenylbutazone, acetazolamide)
  • Medicines for diabetes including insulin
  • Medicines for infection including tuberculosis (rifabutin, rifampicin, amphotericin)
  • Medicines to thin the blood (anticoagulants)
  • Medicines containing oestrogen (the pill [oral contraceptives], hormone replacement therapy)
  • Medicines to suppress your immune system (ciclosporin)
  • Non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin
  • Aminoglutethimide (used for some types of cancer)
  • Methotrexate (used for some types of cancer)
  • Acetazolamide (for glaucoma)
  • Carbenoxolone (used to treat ulcers)
  • Mifeprostone (used for termination of pregnancy)
  • Salicylates
  • Recent vaccines
  • Are using soft contact lenses

Prelone steroid

prelone steroid


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