Non steroidal oestrogen

Tamoxifen is a non-steroidal, triphenylethylene-based drug, which displays a complex spectrum of oestrogen antagonist and oestrogen agonist-like pharmacological effects in different tissues. In breast cancer patients, at the tumour level, tamoxifen acts primarily as an antioestrogen, preventing oestrogen binding to the oestrogen receptor. In women with oestrogen receptor positive/unknown breast tumours, adjuvant tamoxifen has been shown to significantly reduce recurrence of the disease and improve 10-year survival, achieving a significantly greater effect with five years treatment than with 1 or 2 years treatment. These benefits appear to be largely irrespective of age, menopausal status, tamoxifen dose and additional chemotherapy.

After a median duration of therapy of about 30 months and a median follow-up of about 119 months, results showed that sequential treatment with exemestane after 2 to 3 years of adjuvant tamoxifen therapy was associated with a clinically and statistically significant improvement in DFS compared with continuation of tamoxifen therapy. Analysis showed that over the observed study period exemestane reduced the risk of breast cancer recurrence by 14% compared with tamoxifen (hazard ratio , p = ). The beneficial effect of exemestane over tamoxifen with respect to DFS was apparent regardless of nodal status or prior chemotherapy.

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The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) make no judgement on the association between ovarian cancer risk and vegetables; fruits; pulses (legumes); red meat; processed meat; poultry; fish; eggs; milk and dairy products; vegetarian and individual level dietary pattern; coffee; tea; dietary fibre; carbohydrates; protein; total fat; saturated, monounsaturated, and polyunsaturated fatty acids; vegetable and animal fat; trans fatty acids; dietary cholesterol; alcohol; folate; vitamin A; lycopene; vitamin C; vitamin E; serum vitamin D; lactose; calcium; acrylamide; physical activity; abdominal fatness; and energy intake, due to limited evidence.[ 1 ]

Non steroidal oestrogen

non steroidal oestrogen

The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) make no judgement on the association between ovarian cancer risk and vegetables; fruits; pulses (legumes); red meat; processed meat; poultry; fish; eggs; milk and dairy products; vegetarian and individual level dietary pattern; coffee; tea; dietary fibre; carbohydrates; protein; total fat; saturated, monounsaturated, and polyunsaturated fatty acids; vegetable and animal fat; trans fatty acids; dietary cholesterol; alcohol; folate; vitamin A; lycopene; vitamin C; vitamin E; serum vitamin D; lactose; calcium; acrylamide; physical activity; abdominal fatness; and energy intake, due to limited evidence.[ 1 ]

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