Genetics play a role in the development of COPD.  It is more common among relatives of those with COPD who smoke than unrelated smokers.  Currently, the only clearly inherited risk factor is alpha 1-antitrypsin deficiency (AAT).  This risk is particularly high if someone deficient in alpha 1-antitrypsin also smokes.  It is responsible for about 1–5% of cases   and the condition is present in about three to four in 10,000 people.  Other genetic factors are being investigated,  of which many are likely. 
These symptoms can cause seizures and coma. They can even be deadly. Many solvents and aerosol sprays are highly concentrated, meaning they contain a large amount of chemicals with a lot of active ingredients. Sniffing these products can cause the heart to stop within minutes. This condition, known as sudden sniffing death , can happen to an otherwise healthy young person the first time he or she uses an inhalant. Using inhalants with a paper or plastic bag or in a closed area may cause death from suffocation (being unable to breathe).