Once inside the cell, the acidic conditions in the endosome cause two events to happen: First, part of the hemagglutinin protein fuses the viral envelope with the vacuole's membrane, then the M2 ion channel allows protons to move through the viral envelope and acidify the core of the virus, which causes the core to disassemble and release the viral RNA and core proteins.  The viral RNA (vRNA) molecules, accessory proteins and RNA-dependent RNA polymerase are then released into the cytoplasm (Stage 2).  The M2 ion channel is blocked by amantadine drugs, preventing infection. 
This virus is awful! I got it a year ago around this time. Now I have it again. The first time I was sick for about a week
I couldn’t eat or drink anything. Eventually I was able to take small sips of Gatorade. This time around hasn’t been as bad as last time. It still sucks tho. At least I’m able to keep some pedialite down. Also, I’ve noticed the stomach cramps are worse this time, but I’m not violently throwing up like I was last time. It seems the best remedy for this is plenty or rest, pedialite (what you can handle), and let the god awful virus run its course. Hope everybody makes a swiftly recovery!!
Influenza vaccine production begins as early as 6 to 9 months before the beginning of vaccine distribution. Even with this early start, it isn’t possible to complete the entire production and distribution process prior to flu season, in part because of the limited number of influenza vaccine manufacturing plants in the United States and the large number of doses that are produced each year. Instead, influenza vaccine distribution takes place in a phased fashion over a number of months. Distribution usually begins in late summer and is complete near the end of November or early in December. This may result in some uncertainty making it difficult for vaccine providers to plan their vaccination activities. Manufacturers and distributors try to get some vaccine to as many providers as possible as early as possible so that they can begin vaccinating their patients.