Comparative toxicity of nonsteroidal anti-inflammatory agents

Central chromatolysis has been observed in spinal anterior horn and motor neurons of patients with amyotrophic lateral sclerosis (ALS). [11] Patients with ALS appear to have significant alterations that occur within the chromatolyzed neuronal cells. [12] [13] These alterations include dense conglomerates of aggregated dark mitochondria and presynaptic vesicles , bundles of neurofilaments , and a marked increase of presynaptic vesicles. Changes to the function of the motor neurons have also been observed. The most typical functional change in chromatolytic motor neurons is the significant reduction in size of the monosynaptic excitatory postsynaptic potentials (EPSPs). These monosynaptic EPSPs also seem to be prolonged in the chromatolyzed cells of ALS patients. This functional change to the anterior horn neurons could result in the elimination of certain excitatory synaptic inputs and thus give rise to the clinical motor function impairment that is characteristic of the ALS disease. [13]

Jeter (Jay) Pritchard Taylor, III, MD  Assistant Professor, Department of Surgery, University of South Carolina School of Medicine; Attending Physician, Clinical Instructor, Compliance Officer, Department of Emergency Medicine, Palmetto Richland Hospital

Jeter (Jay) Pritchard Taylor, III, MD is a member of the following medical societies: American Academy of Emergency Medicine , American College of Emergency Physicians , American Medical Association , Columbia Medical Society , Society for Academic Emergency Medicine , South Carolina College of Emergency Physicians, South Carolina Medical Association

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Employed contractor - Chief Editor for Medscape.

A second possible criticism is the choice of diethylamine as the test material as this is not an agent normally found in wound exudate although it has a formula weight (FW) of 73, comparable with that of cadaverine, (H2N (CH2)5 NH2, (FW 102)) and putrescine, (H2N (CH2)4 NH2 (FW88)) molecules with which it shares some chemical similarities. Diethylamine has also been used on a number of occasions previously for assessing the performance of charcoal dressings. [14] [15] The use of an alternative test solution such as a bacterial culture was considered prior to commencing this work, but was discounted because no objective system was available to us that could be used to measure odour production from such a complex mixture.

Comparative toxicity of nonsteroidal anti-inflammatory agents

comparative toxicity of nonsteroidal anti-inflammatory agents

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